![]() ![]() J., Mayordomo, F., LeGuern, E., Marin, I., Vilchez, J. (2007) EMBO reports 8, 939–944Ĭuesta, A., Pedrola, L., Sevilla, T., Garcia-Planells, J., Chumillas, M. H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., and Lipton, S. (2008) Proceedings of the National Academy of Sciences 105, 15803–15808Ĭerveny, K. R., Blackstone, C., Bernardi, P., and Scorrano, L. J., Bale, S., Mozdy, A., Tieu, Q., Nunnari, J., and Shaw, J. E., Hulette, C., Dew-Knight, S., Hentati, F., Ben Hamida, M., Bel, S., Stenger, J. (2010) Hum Mol Genet 19, 2113–2122īaricault, L., Segui, B., Guegand, L., Olichon, A., Valette, A., Larminat, F., and Lenaers, G. L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G., Bhattacharya, S. Sentrin/SUMO-specific protease 5 MARCH-V:Īlexander, C., Votruba, M., Pesch, U. Mitochondrial-anchored protein ligase SUMO1: Maintenance of mitochondrial morphology CRD1: Presequence translocase-associated motor MitoPLD: Translocase of the inner mitochondrial membrane 23 PAM: ![]() Skp Cullin, F-box containing complex TIM23: Mitochondrial targeting GxxxG motif BDLP: Ganglioside-induced differentiation protein 1 CMT: Named after the complex mitochondrial network of the yeast mutant NTE:Įucine zipper-EF-hand containing transmembrane protein 1 CaMKIα:Ĭa 2+/calmodulin-dependent protein kinase Iα GDAP1: Guanosine triphosphate effector domain Vps1: Presenilin-associated rhomboid-like GTPase: Mitochondrial deoxyribonucleic acid siRNA:Ĭomplementary deoxyribonucleic acid PARL: Tetracycline-regulatable promoter with 7 regulatory units Phb1/2: Mitochondrial distribution and morphology 10/30/33/36 TetO 7 Mitochondrial genome maintenance 1 Mdm10/30/33/36: Processing of cytochrome c peroxidase 1 Mgm: ![]() Photoactivatible green fluorescent protein Fzo: Further, we will introduce how these membrane dynamics contribute to both organelle and cellular function, and extend these findings to human disease. Here, we will discuss the genetic and biochemical characterization of the molecular machinery that orchestrates these complex processes. This chapter serves as an introduction to the history of mitochondrial research, and also as an introduction to one of the fundamental cell biological nuances of mitochondrial activity, the gymnastics of double membrane fusion and fission. This book describes the most important aspects of mitochondrial function in neurodegeneration. One can hardly pick up one of the top basic research or clinical research journals without seeing a new discovery about mitochondrial function in cellular/human health and disease. Mitochondrial research has undergone a true renaissance in the last few years. ![]()
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